Gathers together research from three key application themes of modelling in operational research - modelling to support evaluation; modelling within the development; and the use of modelling approaches to enhance decision support in organisational contexts. This book also covers a range of complex and diverse modelling issues.

Trials in the treatment of the leukemias are sometimes based on a hypothesis, as in the case of exchange transfusion 33] or the use of antimetabolites 86]. Or they are conducted empirically as the results of chance observations, as in the case of the use of the nitrogen mustards, urethane, and the Vinca alkaloids. Or they lie between the two, aiming at making use of well established biological facts: examples are the use of ACTH, cortisone and, more recently, the antibiotics. What is true for bacteria may also perhaps be true, if not for elephants, at least for the malignant cells of...