Widespread throughout Latin America, susto is a folk illness associated with a broad array of symptoms. It is considered by susceptible populations to be a sickness caused by the separation of soul and body which is precipitated by a supernatural force. Most studies of culture-bound diseases have relied on descriptive approaches that focus on pathologies derived from medical textbooks. This study takes an interdisciplinary approach, looking for explanations of susto in the interaction of social, physiological, and psychological factors.