This book constitutes the proceedings of the 6th International Workshop on Computational Topology in Image Context, CTIC 2016, held in Marseille, France, in June 2016.

The 24 papers presented in this volume were carefully reviewed and selected from 35 submissions. Additionally, this volume contains 2 invited papers. CTIC covers a wide range of topics such as: topological invariants and their computation, homology, cohomology, linking number, fundamental groups; algorithm optimization in discrete geometry, transfer of mathematical tools, parallel computation in multi-dimensional...