Proceedings of the May 1995 meeting, detailing the cooperative substructure of protein molecules and the inherent mobility of biomolecular edifices. Topics include solution structure of the long neurotoxin LSIII with possible implications for binding to the acetylcholine receptor; NMR studies of enz

This volume is a collection of articles from the proceedings of the International School of Structural Biology and Magnetic Resonance 3rd Course: Protein Dynamics, Function, and Design. This NATO Advance Study Institute was held in Erice at the Ettore Majorana Centre for Scientific Culture on April 16-28, 1997. The aim of the Institute was to bring together experts applyipg different physical methods to problems of macro molecular dynamics-notably x-ray diffraction, NMR and other forms of spectroscopy, and molecular dynamics simulations. Emphasis was placed on those systems and types of...

From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu- tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane...