The cutting-edge Purine and Pyrimidine Metabolism in Man IX brings together contributions from internationally recognized researchers in the fields of molecular genetics, biochemical pharmacology, biochemistry, developmental biology, immunology, and epidemiology. This research has been crucial for the develoment of potent anticancer and antiviral drugs. A sampling of topics includes -- gout -- adenosine -- inborn errors of purine and pyrimidine metabolism -- mutations -- effects of hypoxia, free radicals, or reperfusion injury -- hot research areas, and -- cell differentiation and...

th th This volume comprizes articles presented at the joint IX International and 6 Euro- pean Symposium on Purine and Pyrimidine Metabolism in Man held in Gmunden, Austria, June 1 through 7, 1997. Since the first of this series of meetings was held in Israel in 1973, conventions were organized every three years in different parts of the world including the USA, Japan, and Europe. The different aspects of purine and pyrimidine metabolism bring together re- searchers working in molecular genetics, biochemical pharmacology, biochemistry, devel- opmental biology, immunology, epidemiology and the...

The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate in such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also...

The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also...