Dieses Buch beschreibt im Detail die gesamte Geschichte der fruhen wie der modernen wissenschaftlichen Nautik und verdeutlicht, wie elementar wichtig und schwierig zugleich die Bedingungen fruher in der Seefahrt waren. Auch heute noch ein auerst lesenwertes Buch, das dem Leser die Grundlagen der Nautik im Zeitalter vor der Satellitennavgation nahe bringt.

The international workshop on "Specificity and Function of Clonally Developing T Cells" was held at SchloG Rei- sensburg (near UIm, West Germany) on March 17-20, 1985. The meeting brought together immunologists study- ing clonal T-cell development in man and mouse in various in vitro systems at the cellular as well as molecular level. It was an attempt to provide an overview of the current research interests of groups working on (a) the developmen- tal potential of in vitro expanding primary T-cell clones (investigated using limiting dilution analysis) and cloned T -cell lines established in...

Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964). Smaller numbers of lymphocytes migrate from blood to extranodal tissues such as pancreas and then through lymphatic vessels to LN (MACKAY et al. 1990). An important feature of this migration is the ability of lymphocytes to recognize and adhere to the surface of blood vessel endothelial cells before migrating through the vessel wall into surrounding tissue (CARLOS and HARLAN 1994;...

Severe sepsis and septic shock are the most serious compli- cations of bacterial infections. Both gram-positive and gram- negative bacteria can trigger these extreme inflammatory re- sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from...

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On occasion, the innate immune system is referred to as the "primitive" immune system. Perhaps this has dissuaded immu- nologists from analyzing it as energetically as they have analyzed the adaptive immune system during the past two decades. But while its phylogenetic origins are indeed ancient, and though it is "of the first type," there is nothing crude, nothing unsophisti- cated, and nothing "inferior" about innate immunity. On the contrary, the innate immune system has had time to achieve a level of refinement that is nothing short of dazzling, and a modicum of respect is at long last...