Synthesis and characterization of dumbbell oligonucleotides containing loops of phosphodiester , two/ three trimethylene, C3 moieties in each loop and phosphorothioate linkages is described. Incubation of dumbbell oligonucleotides containing loops of phosphorothioate with S-1 did not result in significant cleavage. Binding of dumbbell oligonucleotides to MoMuL Virus reverse transcriptase was evaluated by PAGE band mobility shift assays. Dissociation constants evaluated using PAGE band mobility shift assays were of the order of 10-7. Investigation of inhibition of RNase H activity of...

Plants have been a major resource for health care since more than 2,000 years. One fourth of modern medicines owe their origins of raw material to plants. Many foods consumed in Asia have been traditionally used to cure specific human ailments.However, in the few countries these links to traditional uses remain largely unexplored. Chronic diseases are a major health problem accounting for a high proportion of deaths, disability and illness. These include coronary heart disease, stroke, cancer, dementia, diabetes, asthma and osteoarthritis.Yet many of these diseases are preventable or their...

Hundreds of thousands of patients safely see their dentist every day. However, emergencies can happen anytime, anyplace and the dental office is no exception. The stressful nature of a dental visit can trigger an emergency in sensitive patients Are you prepared to deal with emergencies that may arise during your workday ? The best time to prepare for an emergency is well before it happens.Emergencies aren't planned events, but handling them can be. Basic life support is all that is required to manage many emergency situations, with the addition of specific drug therapy in some...