Reports the deliberations of a working group convened to evaluate the carcinogenic risk to humans posed by the therapeutic use of 15 pharmaceutical drugs. The volume features separate monographs on five antineoplastic agents, four antimicrobial agents, two diuretics, ciclosporin (an immunosuppressant), cimetidine (used in the treatment of gastric and duodenal ulcers), paracetamol (a popular analgesic and antipyretic drug), and dantron (a laxative). Drugs were selected for inclusion on the basis of published data suggesting carcinogenic effects in experimental animals or in human patients...

Reports the deliberations of a working group convened to evaluate the strength of evidence linking the drinking of coffee, tea, and mate to the development of human cancer. Separate evaluations are also provided for caffeine, theophylline theobromine and methylglyoxal, which are chemical constituents of coffee, tea, and several other popular beverages.

The first and most extensive monograph evaluates the large number of studies designed to assess the carcinogenic potential of coffee. On the basis of available data, the working group concluded that coffee is possibly carcinogenic...

Evaluates the carcinogenic risk to humans posed by occupational exposure during the spraying and application of insecticides. The book also features separate monographs evaluating the carcinogenicity of 17 individual pesticides, including several that have been banned by industrialized countries yet are still used in the developing world. Although some of these pesticides have been in use for more than four decades, evaluations of carcinogenicity were hindered by the sparsity of well-designed epidemiological studies.

The first and most extensive monograph evaluates data from...

Evaluates occupational exposures to mists and vapours from strong inorganic acids: and other industrial chemicals.

Evaluates the carcinogenic risk to humans posed by the ingestion of several naturally occurring substances. Separate monographs are presented for two food items (salted fish and pickled vegetables), two naturally occurring plant substances (caffeic acid and d-limonene), four heterocyclic aromatic amines found in cooked meat and fish, and selected mycotoxins, including aflatoxins.

The monograph on salted fish concentrates on fish as traditionally prepared in southern China, where very high rates of nasopharyngeal carcinoma have been linked to the consumption of salted fish prepared...

A detailed assessment of the carcinogenic risk to humans posed by the professional and personal use of hair colourants. An additional 17 monographs evaluate the carcinogenicity of eight hair dyes, one cosmetic colourant, four industrial dyestuffs, and four aromatic amines, three of which are used in dyestuff manufacture.

The first and most extensive monograph considers the carcinogenic risk posed by occupational exposures of hairdressers and barbers and personal exposure to hair colourants. Citing consistent evidence from five large European cohort studies of excess risk for...

Evaluates the carcinogenic risk to humans posed by exposure to selected metals and their compounds. Separate monographs are presented for beryllium and beryllium compounds, cadmium and cadmium, compounds, and mercury and inorganic and methylmercury compounds. Because several metallic salts and pigments are used in the manufacture and coloring of certain glass products, the book also evaluates the carcinogenic risk posed by exposures in the glass manufacturing industry. More than 1200 references to the recent literature are included.

The first monograph evaluates biological and...

Evaluates the carcinogenic risk to humans posed by exposure to fourteen industrial chemicals, including several having considerable commercial importance as the building blocks of widely used polymers and copolymers. While some of these chemicals are evaluated for the first time, the majority have been re-evaluated in the light of substantial new data and more precise methodological guidelines for the interpretation of findings. In view of the widespread industrial use of these chemicals, particular emphasis is placed on the risk of cancer in occupationally exposed workers. Over 1,800 studies...

Evaluates the carcinogenic risks to humans posed by exposure to crystalline and amorphous silica, some silicates (palygorskite, sepiolite, wollastonite, and zeolites other than erionite), coal dust, and para-aramid fibrils. The volume opens with a discussion of the many complexities involved in assessing the cancer risks associated with occupational exposure to inhaled mineral dusts, and the special toxicological considerations required when evaluating the results of experimental studies. Against this background, the first and most extensive monograph evaluates human and animal...

Evaluates the carcinogenic risk to humans posed by exposure to some Pharmaceutical Drugs.