The endothelium, the cell layer that forms the inner lining of blood vessels, is a spatially distributed system that extends to all reaches of the human body. Today, clinical and basic research demonstrates that the endothelium plays a crucial role in mediating homeostasis and is involved in virtually every disease, either as a primary determinant of pathophysiology or as a victim of collateral damage. Indeed, the endothelium has remarkable, though largely untapped, diagnostic and therapeutic potential. This volume endeavors to bridge the bench-to-bedside gap in endothelial biomedicine, with...

This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.

North-east England experienced the Norman Conquest rather differently from the south of the country. This account of events in Northumbria gives an important alternative view of the Conquest and settlement, distinct from the more usual southern and court-centred evidence. A key factor in events was the monastic community of St Cuthbert in Durham, which had survived the political upheavals following the collapse of the Northumbrian kingdom under Scandinavian pressure in the ninth century. Its position thus strengthened, it occupied an influential place in the factors ranged against the...