*-algebras of unbounded operators in Hilbert space, or more generally algebraic systems of unbounded operators, occur in a natural way in unitary representation theory of Lie groups and in the Wightman formulation of quantum field theory. In representation theory they appear as the images of the associated representations of the Lie algebras or of the enveloping algebras on the Garding domain and in quantum field theory they occur as the vector space of field operators or the *-algebra generated by them. Some of the basic tools for the general theory were first introduced and used in these...