This volume looks in depth at the way the brain responds to trauma and subsequently integrates and influences behavioural, metabolic, neurohormonal, cardiovascular and immune functions. It is becoming increasingly clear that the brain has an important role in the control and integration of the responses to injury and infection. It is well established that some of these reponses, such as fever and neuroendocrine changes are directly influenced by the central nervous system. These, and other more recent advances, provide new insights into this area and provide a basis for the more effective...

It is becoming increasingly clear that the brain has an important role in the control and integration of the responses to injury and infection. This is the first volume to look in depth at the way the brain responds to trauma and subsequently integrates and influences behavioral, metabolic, neurohumoral, cardiovascular, and immune functions. It is well established that some of these responses, such as fever and neuroendocrine changes are directly influenced by the central nervous system. These, and other more recent advances, provide new insights into this area and provide a basis for more...

N aney J. Rothwell ytokine neurobiology is now a hot topic Only a few years ago C most neuroscientists were only dimly aware of cytokines and knew little about their function or biological importance. Cytokines, now a huge collection of polypeptides with diverse activities, were until quite recently, studied by those interested in the immune system, inflamma- tion, cancer or infection in peripheral tissues, and did not feature in neuroscience. For example, less than five years ago virtually no refer- ence was made to cytokines in any of the numerous abstracts at the American Society for...