Combinatorial mathematicians and statisticians have made a wide range of contributions to the development of block designs, and this book brings together much of that work. The designs developed for a specific problem are used in a variety of different settings. Applications include controlled sampling, randomized response, validation and valuation studies, intercropping experiments, brand cross-effect designs, lotto and tournaments. The intra- and inter- block, nonparametric and covariance analysis are discussed for general block designs, and the concepts of connectedness, orthogonality, and...

An introduction to state-of-the-art experimental design approaches to better understand and interpret repeated measurement data in cross-over designs.

Repeated Measurements and Cross-Over Designs

• Features the close tie between the design, analysis, and presentation of results
• Presents principles and rules that apply very generally to most areas of research, such as clinical trials, agricultural investigations, industrial procedures, quality control procedures, and epidemiological studies
• Includes many practical examples, such as PK/PD...