"The Texas January day was all blue and gold and barely crisp. Only the absence of leaves and sap, the presence of straggling bands of awkward crows, the gray-yellow flutter of field larks, and the broad, matter-of-fact hibernation of the earth said it was winter as Sam Tucker walked along the road, his long legs functioning automatically, farmerly. His body had about it the look of country dogs at the end of winter, when they are all ribs and leg muscles and jaw muscles and teeth. . . ." Hold Autumn in Your Hand, is the memorable story of Sam Tucker and the year that he contracts to farm...

Almost four decades of innovative and intensive research on Alzheimer's disease (AD) have brought major advances in our understanding of its pathogenesis, improved tools for diagnosis, and strategies for its treatment. This research has helped build a solid foundation of knowledge in the neurosciences and biological basis of AD and AD-related neurological disorders. Scientific background and insightful hypotheses are of major relevance in order to approach to an effective therapy for this devastating disease.

Current Hypotheses and Research Milestones in...

The neuronal cytoskeleton is a complex structure responsive to both intrinsic and extrinsic factors. Defined populations of neurons in the brains of patients with Alzheimer and several other neurodegenerative diseases contain abnormal filamentous accumulations which share elements with the cytoskeleton. Although there is a general consensus that these abnormal filaments do contain cytoskeletal elements, much debate remains regarding which cytoskeletal elements are incorporated and whether the cytoskeletal rearrangement is primary or secondary to other cellular changes. In this book these...