Hamlin's study provides the first full-scale account of the reception and literary appropriation of ancient skepticism in Elizabethan and Jacobean England. Offering abundant archival evidence as well as fresh treatments of Florio's Montaigne and Bacon's career-long struggle with the challenges of epistemological doubt, Hamlin's book explores the deep connections between skepticism and tragedy in plays ranging from Doctor Faustus and Troilus and Cressida to The Tragedy of Mariam, The Duchess of Malfi, and 'Tis Pity She's a Whore.