This book covers both the basic principles of contemporary mass spectrometry instrumentation as well as its application to problems in structural biochemistry. Its tutorial form serves as an introduction to those entering the field, and for established scientists who wish to apply mass spectrometry to structural problems. The expertly written chapters introduce and summarize the capabilities of sector, tandem sector, hybrid, time-of-flight, triple quadrupole, ion trap, and Fourier transform mass spectrometers. New methods, such as electrospray ionization, laser desorption, and high...

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid...

How should and how do democratic citizens behave when governments act unjustly? Do they respond aggressively, armed with universal concern for the rights and interests of all citizens or are they acting from narrow concerns based on special interests and sectarian loyalties? To answer these questions, the author explores social activism on three continents: Jewish rescue in Europe during World War II, abortion politics in the United States, and peace and settler activism in Israel. The answer challenges the strong moral role we often attribute to responsible citizens and emphasizes the...

Asymmetric conflict is changing the way that we practise and think about war. Torture, rendition, assassination, blackmail, extortion, direct attacks on civilians, and chemical weapons are all finding their way to the battlefield despite longstanding international prohibitions. This book offers a practical guide for policy makers, military officers, students, and others who ask such questions as: Do guerillas deserve respect or long jail sentences? Are there grounds to torture guerillas for information or assassinate them on the battlefield? Is there room for nonlethal weapons to subdue...