This book addresses a wide range of recent methodological aspects, applications and best practices of statistics production. It comprises a selection of peer-reviewed contributions of methodological and applied interest presented at the 4th Conference of European Statistics Stakeholders, CESS 2022, held in Rome, Italy, on October 20-21, 2022. The first part discusses statistical methods with applications to environmental risk assessment, sentinels data, surveillance systems during the Covid-19 pandemic, healthcare risk management, the analysis of regional or structural changes of scale,...