Statistical methodology is an essential component of clinical (and biological) - search. Therefore it is not surprising that many textbooks aiming at explaining statistical methods to researchers have been published and continue to appear in print. The complexity of the basic issue, that of communication between st- isticians and researchers, is illustrated and discussed very well by the authors of this book in their Introduction. Thus it would be of no benefit to dwell further on this theme and on the difficulty of producing truly effective material. I prefer to start from a personal...
Statistical methodology is an essential component of clinical (and biological) - search. Therefore it is not surprising that many textbooks aiming at ...
Patients are not alike This simple truth is often ignored in the analysis of me- cal data, since most of the time results are presented for the "average" patient. As a result, potential variability between patients is ignored when presenting, e.g., the results of a multiple linear regression model. In medicine there are more and more attempts to individualize therapy; thus, from the author's point of view biostatis- cians should support these efforts. Therefore, one of the tasks of the statistician is to identify heterogeneity of patients and, if possible, to explain part of it with known...
Patients are not alike This simple truth is often ignored in the analysis of me- cal data, since most of the time results are presented for the "aver...
Statistical methodology is an essential component of clinical (and biological) - search. Therefore it is not surprising that many textbooks aiming at explaining statistical methods to researchers have been published and continue to appear in print. The complexity of the basic issue, that of communication between st- isticians and researchers, is illustrated and discussed very well by the authors of this book in their Introduction. Thus it would be of no benefit to dwell further on this theme and on the difficulty of producing truly effective material. I prefer to start from a personal...
Statistical methodology is an essential component of clinical (and biological) - search. Therefore it is not surprising that many textbooks aiming at ...
Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon.
In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component...
Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affecte...
This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields.
The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in...
This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the li...
The MarkDown interface allows the students to implement the code on their own computer, contributing to a better understanding of the underlying theory. Part I presents methods of inference based on likelihood and Bayesian methods, including computational techniques for fitting likelihood and Bayesian models.
The MarkDown interface allows the students to implement the code on their own computer, contributing to a better understanding of the underlying theor...
