Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprogrammed into induced pluripotent cells (iPS cells) is a significant breakthrough for regenerative medicine. This promises patient-specific tissue for replacement therapies, as well as disease-specific cells for developmental modeling and drug treatment screening. However, this method faces issues of low reprogramming efficiency, and poorly defined criteria for determining the conversion of one cell type to another. Cells contain epigenetic...
Brain diseases can have a large impact on patients and society, and treatment is often not available. A new approach in which somatic cells are reprog...
Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin -- the neurotransmitter which has probably most captured the imagination of laymen and academics alike -- is as elusive as the clinical aspects of serotonergic medications. Why are drugs acting at certain serotonin receptors efficacious against generalized anxiety disorder, but not panic disorder? Why is the inverse true for monoamine oxidase inhibitors? These clinically relevant issues are clarified by the neurochemical, anatomical and physiological...
Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin -- the neurotra...
While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo ("neurosteroids"). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychologicalconditions and neurological diseases. This Brief will...
While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo ("neur...
Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders. Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity. In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol...
Glutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neu...
Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as the "reward center" of the brain, where a number of chemical messengers work in concert to provide a net release of dopamine in the Nucleus Accumbens. In some genetically predisposed individuals, addiction occurs when the mechanisms of the mesolimbic system are disrupted by the use of various drugs of abuse. Since Alcoholics Anonymous was founded in 1935, it's 12 step program of spiritual and character development has helped countless alcoholics...
Humans are biologically programmed to seek out pleasurable experiences. These experiences are processed in the mesolimbic system, also referred to as ...
This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders.
In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The...
This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of actio...
This leading-edge volume offers a new framework for neuropsychological testing rooted in the current evidence base on large-scale brain system interactions. Expert coverage brings traditional discrete areas of cognitive functioning (e.g., attention, memory) in line with highly nuanced relationships between cortical and subcortical processing. The new findings point to more accurate and targeted testing, as authors expand on the judicious addition of nonstandardized methods to core diagnostic tools and the underused capacity of neuropsychological testing to assess social behavior...
This leading-edge volume offers a new framework for neuropsychological testing rooted in the current evidence base on large-scale brain sys...
