About 50 publications out of more than 500 have been selected from the work of Michael Rossmann covering the years from 1958 to 2012. These include his early work with Max Perutz on hemoglobin and the first protein structures to his current work on the structures of small icosahedral and large polymorphic viruses. These papers describe not only some of the first protein and virus structures, but also the crystallographic and electron microscopic technologies. Furthermore, the author's interests include evolution and protein folding. The selected papers are a personal history of structural...

The aim of this book is to make available, to students and experts, a compendium of important articles covering (1) the development of single-article reconstruction techniques, and (2) the progress in the exploration of structural basis of translation in bacteria and eukaryotes by cryo-EM and single-particle reconstruction.For novice and expert alike, a good overview of the development of tools and the ensuing discoveries spanning almost half a century has been lacking. Review articles attempting such an endeavor normally a very limited scope. The purpose of this book is to give the reader...

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell.

This book describes the accomplishments of a curious and imaginative scientist, and his endeavours to translate or even to extrapolate scientific insights into the world of art.The science section in this volume concerns studies on S-layers, a very important class of proteins found on the surface of numerous Bacteria and nearly all Archaea. S-layer proteins are one of the most abundant biopolymers on our planet, and assemble into the simplest type of biological membrane. Moreover, they are unique building blocks and patterning elements for the production of complex supramolecular structures...

This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It...

This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It...