This research monograph discusses newly developed mathematical models and methods that provide biologically meaningful inferences from data on cancer latency produced by follow-up and discrete surveillance studies. Methods for designing optimal strategies of cancer surveillance are systematically presented. This book offers new approaches to the stochastic description of tumour latency, employs biologically-based models for making statistical inference from data on tumour recurrence and also discusses methods of statistical analysis of data resulting from discrete surveillance strategies. It...

Since the mid-1970s, scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms, including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the...

This book is an introductory course to accelerator physics at the level of graduate students. It has been written for a large audience which includes users of accelerator facilities, accelerator physicists and engineers, and undergraduates aiming to learn the basic principles of construction, operation and applications of accelerators. The new concepts of dynamical systems developed in the last 20 years give the theoretical setting to analyze the stability of particle beams in acclerator. In this book a common language to both accelerator physics and dynamical systems is integrated and...

Machine vision technology has created a strong interest among research organizations, resulting in many innovative products. Despite this end users have been very skeptical towards machine vision and its robustness in harsh environments. This book presents the results of a national machine vision technology programme aimed at boosting research and putting research results to work in practical industrial applications. The topics to be covered include image acquisition, analysis of surface colour and texture, applications of machine vision in surface inspection and process control, 3-D...

Developments in the neurosciences have considerably modified our knowledge of both the operating modes of neurons and information processing in the cortex. These developments have led to interest in a coding scheme which relies on precise spatio-temporal patterns from both the theoretical and experimental points of view. Further developments in this field may be of importance for our understanding of the basic mechanisms of perception and cognition. They could also lead to concepts in applications directed towards artificial perception and pattern recognition. This book covers the lectures...

This unique volume presents major developments and trends in bioinformatics and its applications. Comprising high-quality scientific research papers and state-of-the-art survey articles, the book has been divided into five main sections: Microarray Analysis and Regulatory Networks; Machine Learning and Statistical Analysis; Biomolecular Sequence and Structure Analysis; Symmetry in Sequences; and Signal Processing, Image Processing and Visualization. The results of these investigations help the practicing biologist in many ways: in identifying unknown connections, in narrowing down...

Composed of contributions from an international team of leading researchers, this book pulls together the most recent research results in the field of cancer modeling to provide readers with the most advanced mathematical models of cancer and their applications. Topics included in the book cover oncogenetic trees, stochastic multistage models of carcinogenesis, effects of ionizing radiation on cell cycle and genomic instability, induction of DNA damage by ionizing radiation and its repair, epigenetic cancer models, bystander effects of radiation, multiple pathway models of human colon cancer,...

This text gives a description of the state of art in theoretical and experimental work achieved in radiation source development. It summarizes the basic physical aspects, and also provides sufficient literature to enable the reader to follow the development in more detail.