Nitric oxide is an endogenously produced gas with a wide range of biological effects and has been implicated in many physiological and pathophysiological processes. It is released by many cell types in various organs but is particularly important in the maintenance of normal lung function. Nitric oxide in exhaled breath has been identified as a marker for lung disease in some patients. Thus, it is appropriate to consider the lung separately for the role and functioning of nitric oxide. The authors identify key areas in the history, biochemistry, physiology, pathophysiology, immunology and...
Nitric oxide is an endogenously produced gas with a wide range of biological effects and has been implicated in many physiological and pathophysiologi...
1. 1. Invasive versus Non-Invasive Clinical Measurements in Medicine Clinical measurement has become an essential complement to traditional physical diagnosis. An ideal clinical measurement should be quantitative, have a high level of reliability and accuracy, be safe, acceptable to the patient, easy to perform and non-invasive. The latter demands that the technique should not break the skin or the lining epithelium and should be devoid of effects on the tissues of the body by the dissipation of energy or the introduction of infection 1]. It is therefore logical that for a given measurement,...
1. 1. Invasive versus Non-Invasive Clinical Measurements in Medicine Clinical measurement has become an essential complement to traditional physical d...
The lung and its contiguous structures are commonly involved in several of the rheumatic diseases (Table 1), either by direct manifestation of disease or as a secondary effect from infection or complications of therapy. In this chapter, we detail the various pulmonary manifestations of the major rheu matological conditions. The common symptoms of pulmonary diseases and how frequently they are implicated in rheumatic disorders are review ed. In addition, radiology and physiology of the lung, diagnostic proce dures and therapeutic options are discussed. Table l. Respiratory associations of the...
The lung and its contiguous structures are commonly involved in several of the rheumatic diseases (Table 1), either by direct manifestation of disease...
Focussed specifically on children and pediatric respiratory diseases, "The Pediatric Lung+" reviews the current status of pharmacological therapy for asthma, viral pneumonia, cystic fibrosis, bronchopulmonary dysplasia and acute respiratory failure. A review of aerosol delivery systems in children and an up-to-date treatise on mucolytic agents is also included. The chapters are written by leading specialists in the field and summarize the latest developments in pediatric pulmonology, as well as covering a comprehensive range of respiratory diseases in children. Pediatric pulmonologists,...
Focussed specifically on children and pediatric respiratory diseases, "The Pediatric Lung+" reviews the current status of pharmacological therapy for ...
Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to the pathophysiology of a number of severe bronchial diseases, including asthma, chronic bronchitis and cystic fibrosis. This volume provides wide ranging and in-depth coverage of the scientific and clinical aspects of airway mucus. It commences with introductory chapters which address the biochemical and molecular biological basis of airway mucus and continues with comprehensive coverage of the various physiological and rheological aspects of...
Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract. In contrast, when abnormal, mucus contributes significantly to ...
Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. This book results from two recent International Association for the Study of Lung Cancer (IASLC) Workshops on lung cancer prevention. It strikes a balance between considering public health approaches to tobacco control and population-based screening, advances in clinical evaluation of chemoprevention approaches, and the biology of lung carcinogenesis. Indeed, while the science of smoking cessation is evolving as new pharmacological tools are moving into...
Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. This book r...
Many factors may influence the release of neurotransmitters from airway nerves 1]. This is likely to be important in physiological control of airway functions and may be particularly relevant in airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Neural elements in airways interact in a complex manner and the activation of certain neural pathways may profoundly influence the release of transmitters from other neural pathways. Similarly inflamma- tory mediators released from inflammatory cells in the airways may also modulate neurotransmitter release. There are...
Many factors may influence the release of neurotransmitters from airway nerves 1]. This is likely to be important in physiological control of airway ...
