It is hardly necessary to define the concept of receptors to readers of this series, but it should be borne in mind that in several instances receptors are undefined entities, whose molecular details remain to be established. On the other hand the ligand, which recognizes the receptors, has been identified and characterized in most cases. The current interest in the structure and function of biological membranes gives great expectations that we may understand in the near future the details of ligand-receptor interaction. This interaction involves two defined steps: the first, usually referred...
It is hardly necessary to define the concept of receptors to readers of this series, but it should be borne in mind that in several instances receptor...
Fifty-odd years have elapsed since the first observation of the response of visceral smooth muscle to an adenine nucleotide was reported by Drury and Szent Gyorgi (1929). It is now known that purinergic receptors mediating responses to adenosine and the adenine nucleotides (AMP, ADP and ATP) are present in all types of visceral smooth muscle. Adenine itself and other endogenous purine derivatives appear to have no direct effects, or only minimal effects, on most visceral smooth muscles. Airway smooth muscle is an exception in this regard, and responds to purine bases and non-adenine...
Fifty-odd years have elapsed since the first observation of the response of visceral smooth muscle to an adenine nucleotide was reported by Drury and ...
Bacteria adhere to and colonize almost any surface. Within minutes after sub merging a solid object in seawater or freshwater, the surface becomes colonized by adherent micro-organisms, and the earliest organisms to adhere are bacteria. Adherent colonies of bacteria have also been observed on particles of sand, soil, other bacteria, plant tissues, and a variety of animal tissues. Shortly after birth, the skin and the mucosal surfaces of the upper respiratory tract and the gastro intestinal tract of animals and man become heavily colonized by a variety of adherent bacteria which persist in...
Bacteria adhere to and colonize almost any surface. Within minutes after sub merging a solid object in seawater or freshwater, the surface becomes col...
This new se ries is concerned with intercellular communication and recognition. It is now widely appreciated that these processes playa crucial role in virtually all biological systems and functions. These encompass fertilisation, embryonic development, infectious interactions, the activity of the nervous system, the regulation of growth and develop ment by hormones and the immune response to foreign or 'non-self antigens. Historically as described in the first review in this volume, the general concept of cell-associated receptors as the molecular entity primarily responsible for the...
This new se ries is concerned with intercellular communication and recognition. It is now widely appreciated that these processes playa crucial role i...
