Over the last few years remarkable progress has been accomplished with respect to our understanding of nuclear structure and trafficking. This volume concentrates on aspects that involve or are of relevance to RNA and RNPs. Topics include fundamental advances and current problems in the structural organization of different subnuclear compartments: chromatin, nucleolus and perinucleolar compartment, Cajal bodies and gems, speckles containing splicing factors, as well as the PML bodies characteristic of ProMyelocytic Leukemia. It also describes recent progress in the dynamic aspects of RNA...
Over the last few years remarkable progress has been accomplished with respect to our understanding of nuclear structure and trafficking. This volu...
This book constitutes a carefully arranged selection of papers presented at the Forum on Research and Technology Advances in Digital Libraries, ADL'95, held in McLean, Virginia, USA in May 1995. Besides 15 revised refereed technical contributions, the book presents four invited survey papers by key persons heading institutions and projects essentially advancing the state of the art: France Cordova (NASA), James H. Billington (The Library of Congress), Raj Reddy (CMU), and Larry Smarr (NCSA, University of Illinois). The technical papers are organized in topical sections on visualization,...
This book constitutes a carefully arranged selection of papers presented at the Forum on Research and Technology Advances in Digital Libraries, ADL'95...
Inorganic polyphosphates - polymers of orthophosphate linked by high-energy phosphoanhydride bonds - have been found in apparently all forms of life, from bacteria, yeasts and fungi to higher plants and animals. These polymers, which had been neglected for a long time, have become a fascinating area of research in the last few years. This volume summarizes the present state of knowledge about the metabolism and function of inorganic polyphosphates. In addition, the methods to study these polymers as well as the biotechnological applications of inorganic polyphosphates are described. The 15...
Inorganic polyphosphates - polymers of orthophosphate linked by high-energy phosphoanhydride bonds - have been found in apparently all forms of life, ...
This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both the ERK and stress-activated pathways. It further explores two agents that inhibit protein synthesis, calcium and the immunosuppressant rapamycin. Six chapters written by leading experts in the field provide both new data and comprehensive literature reviews. Both the regulation of initiation and elongation are discussed, and the mechanisms of apoptosis are related to changes in the protein synthesis machinery.
This volume presents the response of the eukaryotic translational apparatus to cellular stress and apoptosis, including kinases activated through both...
Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na] channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of...
Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of act...
Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence.
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while...
Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence.
This is the first book on molluscs as sources for pharmaceutical drugs. Marine molluscs are very promising candidates for a wide range of biotechnological applications. For example, they possess analgesic drugs more potent than morphine and very effective anticancer agents. International experts provide coverage of the most stimulating topics related to molluscs. This knowledge of their history and current studies opens the door to the future.
This is the first book on molluscs as sources for pharmaceutical drugs. Marine molluscs are very promising candidates for a wide range of biotechno...
Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.
Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medic...
The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids together, and through its centromere DNA-protein complex known as the kinetochore binds spindle microtubules to bring about accurate chromosome movements. Despite this conserved function, centromeres exhibit dramatic difference in structure, size, and complexity. Extensive studies on centromeric DNA revealed its rapid evolution resulting often in significant difference even among closely related species. Such a plasticity of centromeric DNA could...
The centromere is a chromosomal region that enables the accurate segregation of chromosomes during mitosis and meiosis. It holds sister chromatids tog...
Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence.
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility. The other one deals with parental genomic imprinting, a process which allows to express a few selected genes from only one of the parental allele while...
Epigenetics refers to heritable patterns of gene expression which do not depend on alterations of genomic DNA sequence.
