nomenon 26]. Indeed, Krieg et al. 21] showed that the elimination of the CpG in a particular ODN invariably abolished immune stimulation, but changes in the ODN sequences that did not affect the CpG or the flanking bases did not alter the immuno stimulatory (IS) effect. Furthermore, they extended the initial observations of the IS effects to non-palindromic CpG-enriched ODN 21]. Subsequent studies showed that CpG-enriched ODN also induce the secretion of IL-6 and IL-12 19] and IFN-a 6, 27]. By adding or deleting various IS sequences (ISS)-ODN to or from different pDNAs, it was...
nomenon 26]. Indeed, Krieg et al. 21] showed that the elimination of the CpG in a particular ODN invariably abolished immune stimulation, but change...
In spite of tremendous scientific progress over the past years, cell biologists do not yet understand the fundamental processes that determine the life cy cle of a cell. Such are: cell movement and cell spreading, cell division, cell communication, cell signaling, cell regeneration and cell death. Biochemistry has enabled us to recognize and to isolate an overwhelming number of new proteins. In vitro assays and the reinjection of proteins into cells and tissues have provided insights into molecular functions and cellular mechanisms. The renaissance of the genetic approach by applying...
In spite of tremendous scientific progress over the past years, cell biologists do not yet understand the fundamental processes that determine the lif...
A better "casting" could not be conceived. The authors of this book are gold smiths on the subject. I have followed their work since their "entry" into cyto genetics and I have a high esteem for them. I consider it an honour to be asked to write the preface of their opus. Paul Popescu, Directeur de Recherche at INRA, has also played a promi nent part in the development of animal cytogenetics, especially in domestic animals. He is able to tell you the cost of a translocation in a pig breeding farm or a cow population: a fortune P. Popescu has played a great part in gene mapping of these...
A better "casting" could not be conceived. The authors of this book are gold smiths on the subject. I have followed their work since their "entry" int...
This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem...
This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and nov...
