This new volume in the venerable Organic Reactions series comprises two chapters written in part by the inventors of the unique and important name reactions discussed in these chapters. The first chapter describes a truly remarkable transformation of carboxylic acid derivatives into heteroatom-substituted cyclopropanes, now known as Kulinkovich Cyclopropanation. The second chapter represents an homage to one of the giants of organic chemistry, Sir Derek H. R. Barton. This chapter covers the radical deoxygenation of secondary alcohols that has become known as the Barton-McCombie Reaction.
This new volume in the venerable Organic Reactions series comprises two chapters written in part by the inventors of the unique and important name rea...
Allylic boron compounds have gained a prominent position as a truly practical class of synthetic reagents in the past twenty-five years. Their main application as a method for the stereoselective synthesis of homoallylic alcohols by allyl-transfer to carbonyl compounds is essentially unmatched. In this process, a new carbon-carbon bond is formed, and up to two new stereogenic centers are created in a predictably controlled manner. Highly effective and general enantioselective variants are available, with countless applications in the total syntheses of polyacetate and polypropionate...
Allylic boron compounds have gained a prominent position as a truly practical class of synthetic reagents in the past twenty-five years. Their main...
This volume in the venerable Organic Reactions series contains three chapters focusing on the introduction or the removal of nitrogen from organic compounds. The first chapter features a classic chemical reaction for introducing nitrogen into organic compounds, namely the Schmidt Reaction. The second chapter highlights a less-well-known yet fascinating transformation that introduces nitrogen into organic compounds, The Neber Rearrangement. The third chapter describes an unusual class of reactions that involve the loss of small molecular fragments from a ring, where separate carbon atoms unite...
This volume in the venerable Organic Reactions series contains three chapters focusing on the introduction or the removal of nitrogen from organic com...
Volume 79 in the venerable Organic Reactions series contains two chapters. The first addresses cross-coupling reactions of organotrifluoroborate salts, useful in the development of natural products, materials, and pharmacologically active substances. It is an excellent companion to two previous chapters on tin-based and silicon-based cross-couplings contained in Volumes 50 and 75, respectively. The second chapter addresses asymmetric transformations by deprotonation using chiral lithium amides, useful in target-oriented synthesis, and representing one of the most powerful workhorse reactions...
Volume 79 in the venerable Organic Reactions series contains two chapters. The first addresses cross-coupling reactions of organotrifluoroborate salts...
Volume 80 in the venerable Organic Reactions series contains two chapters. The first describes the use of chiral rhodium complexes to effect catalytic, asymmetric carbon-hydrogen insertion reactions intramolecularly. It details the structural scenarios in which diazocarbonyl compounds can be generated and activated to form, inter alia, lactones, lactams and cyclic ketones. The second chapter describes the use of (chiral) rhodium complexes in combination with diazocarbonyl compounds, but in this case to effect a remarkable transformation that dramatically increases the molecular complexity of...
Volume 80 in the venerable Organic Reactions series contains two chapters. The first describes the use of chiral rhodium complexes to effect catalytic...
Volume 81 represents the confluence of two rare and important phenomena for chapters in the Organic Reactions series, namely, it is a single-chapter volume, and it contains a name reaction coauthored by the inventor. Of the 261 chapters published thus far, only seven have been of sufficient impact to appear as single-chapter volumes. The single chapter in this volume entitled -The Krapcho Dealkoxycarbonylation Reaction of Esters with a-Electron-Withdrawing Substituents- has been coauthored by A. Paul Krapcho together with Organic Reactions' long-time contributor Engelbert...
Volume 81 represents the confluence of two rare and important phenomena for chapters in the Organic Reactions series, namely, it is a single...
Volume 82 describe reactions that involve one of the most common transformations in organic chemistry, namely, the pairwise combination of double bonded functional groups. The importance of this enormous family of reactions is a reflection of the spectacular diversity of precursors and products that can arise from appropriate modulation of reactivity of the partners and especially selection of reagents that dictate the outcome.
The first chapter authored by Takeshi Takeda and Akira Tsubouchi describes the combination of carbonyl compounds in the presence of highly reactive, low...
Volume 82 describe reactions that involve one of the most common transformations in organic chemistry, namely, the pairwise combination of double b...
The two chapters in Volume 84 describe transition metal catalyzed processes that form carbon-carbon bonds and carbon-oxygen bonds in very interesting and practical ways. The first chapter authored by Christina Moberg describes an important subset of one of the earliest and most important enantioselective carbon-carbon bond forming reactions that employ transition metal complexes, namely molybdenum-catalyzed, asymmetric allylic alkylations. The second chapter authored by Brian W. Michel, Laura D. Steffens, and Matthew S. Sigman deals with one of the oldest examples of transition metal...
The two chapters in Volume 84 describe transition metal catalyzed processes that form carbon-carbon bonds and carbon-oxygen bonds in very interesting ...
Volume 85 represents the ninth single chapter volume to be produced in OrganicReactions' 72-year history. The original authors, Drs. Shaughnessy and DeVasher, have compiled an enormous (and growing) literature and distilled it into an extraordinarily useful treatise on all aspects of the copper-catalyzed amination process. Given the myriad types of nitrogen-based nucleophiles and various ligand sets and reaction conditions, the authors have done an outstanding job of identifying the best options for various permutations of donor and acceptor. This comprehensive treatment of...
Volume 85 represents the ninth single chapter volume to be produced in OrganicReactions' 72-year history. The original authors, Drs....
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. Numerous detailed procedures illustrate the significant modifications of each method. Includes tables that contain all possible examples of the reaction under consideration.
The latest volume in this series for organic chemists in industry presents critical discussions of widely used organic reactions or particular phases ...
