This reference work evaluates synthesis methods and considers methods that show promise for future applications. The text describes efficient synthetic methods for the synthesis of both natural and artificial large peptide and protein molecules. Subjects include an introduction to basic topics, linear solid-phase synthesis of peptides, peptide synthesis in solution, convergent solid-phase synthesis, methods for the synthesis of branched peptides, formation of disulfide bridges, and more.

The concept of concerted mechanisms was formulated nearly 90 years ago. Over the last two decades, substantial advancements made in the development of precise methods for elucidating concerted mechanisms have heightened the need for a comprehensive text on the subject. This work gathers the salient materials related to this emerging field into a single text. It sets forth the definition of concertedness along with working sub-definitions and describes experimental tools chemists can use to diagnose the existence or absence of concerted mechanisms.

This book examines methods particularly well suited for either a- or b-C-glycoside formation. It helps field workers quickly select the best method for synthesizing a particular type of C-glycoside. The use of C-glycosides as synthons in natural product synthesis is also addressed.