The International Life Sciences Institute (ILSI) was estab lished to stimulate and support scientific research and edu cational programs in nutrition, toxicology, and food safe ty; and to encourage cooperation in these programs among scientists from universities, industry, and government in order to facilitate the resolution of health and safety issues. The officers and trustees of ILSI believe that questions re garding health and safety are best resolved when govern ment and industry rely on scientific investigations, analy ses, and reviews by independent experts. This process is furthered...

During the years that have intervened since the third volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Digestive System, was published, new information of interest to pathologists has developed at a rather remarkable pace. Standardized nomenclature has been proposed and gained significant acceptance during the period since the first edition and is being utilized on an international basis. This has resulted in improvement in communi cation of pathologic data to regulatory agencies and in scientific publica tions worldwide. This monograph...

Approximately ten years have elapsed since the second volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Respiratory System, was first completed. New in formation of interest to pathologists has developed at a rather remark able pace during these years. Exceptional progress has been made in the routine identification of enzymes and cell products in respiratory cells. A better understanding has developed on the functions of cells of the respiratory tract and of the mechanisms involved in cell metabolism, particularly those involving toxins...

Several compounds are associated with experimentally induced neoplasms in the urinary systems, and especially the kidneys, of laboratory animals. Many of these neoplasms are succintly described and illustrated in detail in this volume, and some are compared with spontaneously occurring lesions. Pragmatic aspects of disease which are of particular interest to pathologists are emphasized, such as classification and differential diagnosis of neoplasms that occur in the urinary system; comparison and significance of toxic effects of substances in animals and humans; and similarities and...

Approximately 10 years have elapsed since the first volume of the International Life Sciences Institute (ILSI) Monographs on Pathology of Laboratory Animals, Endocrine System was completed. New information of interest to pathologists has developed at a rather remarkable pace during the intervening years. Exceptional progress has been made in the routine identification of cell products in endo crine cells. A better understanding has developed of the mechanisms involved in cell metabolism, particularly involving toxins and car cinogens. Clear concepts have developed concerning the significance...

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicologic testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common...

The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmon ize toxicological testing, to advance a more uniform inter pretation of bioassay results worldwide, to promote a common...