This book is the first comprehensive volume on the "Nramp family," highlighting the physiological importance of Nramp proteins as metal transporters. The molecular knowledge of these membrane proteins is presented from an evolutionary perspective, considering Nramp cellular function and mechanism of transport in key model organisms. The pathological significance of Nramp genetic polymorphism is discussed with emphasis on metal homeostasis and microbial infection. The chapters were contributed by leading investigators, providing a timely state of the art book in this rapidly growing field....
This book is the first comprehensive volume on the "Nramp family," highlighting the physiological importance of Nramp proteins as metal transporter...
Early Thoughts on RNA and the Origin of Life The full impact of the essential role of the nucleic acids in biological systems was forcefully demonstrated by the research community in the 1950s. Although Avery and his collaborators had identified DNA as the genetic material responsible for the transformation of bacteria in 1944, it was not until the early 1950s that the Hershey-Chase experiments provided a more direct demonstration of this role. Finally, the structural DNA double helix proposed by Watson and Crick in 1953 clearly created a structural frame work for the role of DNA as both...
Early Thoughts on RNA and the Origin of Life The full impact of the essential role of the nucleic acids in biological systems was forcefully demonstra...
The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to affect diverse cellular function and play a role in many pathologies including protein folding disorders, cardiac pathologies, cancer and autoimmunity. This book contains contributions from the world leaders in the area of endoplasmic reticulum function, protein folding, Calcium homeostasis and autoimmunity. It raises many intriguing questions about calreticulin, calnexin and the endoplasmic reticulum and gives a unique opportunity to realize the...
The book focuses on the latest discoveries on calreticulin, calnexin and other endoplasmic reticulum proteins. Calreticulin has been implicated to aff...
Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. In this book, the most significant advances in recent basic research on Protein Kinase C are explained by active researchers in the field. The first seven chapters provide a comprehensive account of the fundamental structural and biochemical properties of Protein Kinase C. The remaining chapters contain overviews of the function of Protein Kinase C, both in lower organisms and in mammalian cells, the latter with...
Protein Kinase C is a pivotal component of the mechanism that allows a cell to respond to its changing environment. In this book, the...
As the first comprehensive overview of the nucleolus since 1985, The Nucleolus covers our current understanding of the cell nucleolus, including its role in ribosome assembly and its additional newly-discovered activities. The eighteen chapters have been written by experts who are actively engaged in research on the nucleolus and have an in depth review of the following topics:
- nucleolar ultrastructure and dynamics, - behavior during mitosis, - ribosomal DNA gene and chromatin structure, - pre-ribosomal RNA transcription, - processing and modification,...
As the first comprehensive overview of the nucleolus since 1985, The Nucleolus covers our current understanding of the cell nucleolus...
Eukaryotic DNA Damage Surveillance and Repair contains chapters from experts in the field of DNA damage detection, repair, and cell cycle control. The work reviews current understanding of how different types of DNA damage are detected and focuses on how these surveillance mechanisms are coupled to processes of DNA repair, cell cycle control, and apoptosis. The title will be of interest to undergraduate/postgraduate students and academics alike.
Eukaryotic DNA Damage Surveillance and Repair contains chapters from experts in the field of DNA damage detection, repair, and cell c...
Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factors, cytokines and cell adhesion proteins. Our knowledge about Rho GTPases has rapidly expanded over the past several years and Rho GTPases is the first book to provide a comprehensive overview of the regulation and functions of this important class of proteins. This book includes several chapters dedicated to the review of various classes of proteins that control the localization and activation state of Rho GTPases....
Members of the Rho family of small GTP-binding proteins (GTPases) are key signal transduction proteins that mediate signals initiated by growth factor...
This volume is devoted to cancer and atherosclerosis, two of the most important proliferative pathologies in the world today. This book provides a useful point of reference on the mechanisms that link cholesterol esters to cell proliferation, summarizing the latest advances both in basic science and clinical research.
This book will be of undoubted value to biomedical students and teachers, as well as those actively engaged in research on cholesterol metabolism, cancer, and atherosclerosis.
This volume is devoted to cancer and atherosclerosis, two of the most important proliferative pathologies in the world today. This book provides a ...
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings togeth...
This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this volume includes several new twists not previously addressed in the literature. In the last few years, the study of protein translocation has been revolutionized by the availability of structural information on many of the components and complexes involved in the process. Unlike earlier books written on protein translocation, this volume considers these advances. In addition, several chapters discuss facets of protein translocation from a systems...
This book addresses the most recent advances in the transport of proteins across a variety of biological membranes. In addressing this topic, this ...
