This open access book documents the use of radiogenic and stable isotopes to study mineral deposits from a global to the deposit scale. It includes data-sets that have been directly used in mineral exploration. Isotopic data have been key to developing models for the origin of many mineral deposit types. The book has four sections: (1) the use of radiogenic isotopes to date mineral deposits, (2) the use of radiogenic isotope mapping to understand metal sources and regional- to district-scale controls on metallogenesis, (3) the use of light stable isotopes to determine fluid and sulfur...