Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment.
This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new...
Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing...
Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful...
Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of t...
Hepatitis Delta Virus is an up-to-date guide to hepatitis D virus (HDV), a human virus with a number of distinctive features. Each chapter of this book describes one of the broad aspects of HDV from virology to molecular biology, and from diagnosis to therapy.
Hepatitis Delta Virus is an up-to-date guide to hepatitis D virus (HDV), a human virus with a number of distinctive features. Each chapter of this boo...
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
"
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyp...
The objective of The Posterior Intrahepatic Approach in Liver Surgery is to describe techniques, as the more routine application today of split liver, living donor transplantation has continued to teach us more about the anatomy of the liver and its applications. Furthermore, laparoscopic surgery in general has grown space and it is important to show the application of the posterior approach in laparoscopic liver surgery as well.
The objective of The Posterior Intrahepatic Approach in Liver Surgery is to describe techniques, as the more routine application today of split liver,...
membrane contamination and thus could then be used to study transport function when pre- pared as membrane vesicles. These approaches defined a number of transport functions in the plasma membranes of hepatocyres and ultimately led to the recognition that bile salts and 3 25 other solutes were transported into bile largely by ATP dependent transport mechanisms.2 - The advent ofmolecular cloning techniques and cellular expression systems rapidly acceler- ated progress in this field and led to the molecular characterization ofmost ofthe major mem- brane transport proteins that determine both...
membrane contamination and thus could then be used to study transport function when pre- pared as membrane vesicles. These approaches defined a number...
VEGF and Cancer is a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (VEGF) in cancer. Key Features: -Discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis, -Review of the biology, molecular properties and regulation of VEGF, -Discussion of the role of VEGF in a range of different tumor types, both solid tumors and haematological cancers, -Review of the therapeutic potential of different approaches to block VEGF, -Review of recent evidence that in addition to its...
VEGF and Cancer is a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (V...
New Bacterial Vaccines focuses upon unfulfilled needs for bacterial vaccines. The increase in drug resistance among many bacterial species has increased the need for new bacterial vaccines. This book serves as a comprehensive reference on the major aspects of developing new bacterial vaccines. The distinctive feature of this book is that it focuses upon new vaccines now under development by reviewing key issues for each vaccine target and new technologies being applied to developing new vaccines. This book should prove useful for students in the life sciences, scientists,...
New Bacterial Vaccines focuses upon unfulfilled needs for bacterial vaccines. The increase in drug resistance among many bacterial sp...
Historical Introduction The Marfan Syndrome: From Clinical Delineation to Mutational Characterization, a Semiautobiographic Account VictorA. McKusick l n 1876, E. Williams, an ophthalmologistin Cincinnati, Ohio, described ectopia lentis in a brother and sister who were exceptionally tall and had been loosejointed from birth. I Although there is a Williams syndrome that has aortic manifestations (supravalvar aortic stenosis), the name Williams was never associated with the disorder we now call Marfan syndrome. The reason is clear: Williamswas geographically removed from the leading medical...
Historical Introduction The Marfan Syndrome: From Clinical Delineation to Mutational Characterization, a Semiautobiographic Account VictorA. McKusick ...
This is the only book to specifically combine basic information on molecular biology with current thinking in cardiac development. The authors clearly illustrate that molecular biology has already provided a wealth of new approaches to the investigation of cellular processes at the molecular level and is now making a significant contribution to the understanding of the role played by such mechanisms in cardiac development. Furthermore, it is shown that this rapidly-expanding field provides an insight into the molecular events underlying cardiac malformation and disease.
This is the only book to specifically combine basic information on molecular biology with current thinking in cardiac development. The authors clearly...
