These notes originated as part of a lecture series on Stochastics in Biological Systems at the Mathematical Biosciences Institute in Ohio, USA. In this contribution the author uses multitype branching processes with mutation to model cancer. With cancer progression, resistance to therapy, the time of the first type $k$ mutation, and $sigma_k$, the time of the first type $k$ mutation that founds a family line that does not die out, as well as the growth of the number of type $k$ cells. The last three sections apply these results to metastasis, ovarian cancer, and tumor heterogeneity. Even...

This book focuses on counting processes and continuous-time Markov chains motivated by examples and applications drawn from chemical networks in systems biology. The book should serve well as a supplement for courses in probability and stochastic processes. While the material is presented in a manner most suitable for students who have studied stochastic processes up to and including martingales in continuous time, much of the necessary background material is summarized in the Appendix. Studentsand Researcherswith a solid understanding of calculus, differential equations and elementary...