Solid state NMR is rapidly emerging as a universally applicable method for the characterization of ordered structures that cannot be studied with solution methods or diffraction techniques. This proceedings -; from a recent international workshop - captures an image of the latest developments and future directions for solid state NMR in biological research, particularly on membrane proteins. Detailed information on how hormones or drugs bind to their membrane receptor targets is needed, e.g. for rational drug design. Higher fields are bringing clear improvements, and the power of solid state...
Solid state NMR is rapidly emerging as a universally applicable method for the characterization of ordered structures that cannot be studied with solu...
It is a truism of science that the more fundamental the subject, the more universally applicable it is. Neverthelens, it is important to strike a level of "fundamentalness" appropriate to the task in hand. For example, an in-depth study of the mechanics of motor cars would tell one nothing about the dynamics of traffic. Traffic exists on a different "level" - it is dependent upon the existence of motor vehicles but the physics and mathematics of traffic can be adequately addressed by considering motor vehicles as mobile "blobs," with no consideration of how they become mobile. To start a...
It is a truism of science that the more fundamental the subject, the more universally applicable it is. Neverthelens, it is important to strike a leve...
NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR...
NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NM...
During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or...
During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biolog...
It was twenty ?ve years ago this year that for the ?rst time a protein under- ing a form of human cerebral amyloidosis, the Icelandic-type hereditary cerebral haemorrhage was identi?ed. This, together with the recognition that an amino acid substitution can transform the wild type cystatin C into a disease-associated amyloid-forming protein in this condition, was only a prelude to a series of imp- tant discoveries that followed. As a result, pathologically altered proteins have been brought into the centre stage of research into the pathomechanism of a n- ber of neurodegenerative diseases,...
It was twenty ?ve years ago this year that for the ?rst time a protein under- ing a form of human cerebral amyloidosis, the Icelandic-type hereditary ...
Solid state NMR is rapidly emerging as a universally applicable method for the characterization of ordered structures that cannot be studied with solution methods or diffraction techniques. This proceedings -; from a recent international workshop - captures an image of the latest developments and future directions for solid state NMR in biological research, particularly on membrane proteins. Detailed information on how hormones or drugs bind to their membrane receptor targets is needed, e.g. for rational drug design. Higher fields are bringing clear improvements, and the power of solid state...
Solid state NMR is rapidly emerging as a universally applicable method for the characterization of ordered structures that cannot be studied with solu...
This text is aimed at a student readership but will also be useful to life science researchers faced with the task of isolating a protein.
The logic of the overall approach to protein isolation is explained and the physical principles of each separation method are made clear by the use of simple models and analogies drawn from everyday experiences. The author's aim has been to deepen the readers' insight into protein isolation methods, so that they may tackle new problems and perhaps devise new approaches to old problems. Many of the methods described are drawn from the author's own...
This text is aimed at a student readership but will also be useful to life science researchers faced with the task of isolating a protein.
During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or...
During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biolog...
NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR...
NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NM...
