Cognitive function involves the participation of many different neurotransmitter systems in a variety of brain areas. The centerpiece of investigation regarding cognitive function has classically been the cholinergic system, but it has beome increasingly clear that other transmitter systems interact with cholinergic systems to provide the neural basis for cognitive function.

This book brings together cutting edge research to determine how the transmitter interactions form the mechanistic bases for attention, learning and memory. This research on transmitter interactions not...

The special issue contains contributions presented at the international workshop Seismic waves in laterally inhomo- geneous media IV, which was held at the Castle of Trest, Czech Republic, May 22-27, 1995. The workshop, which was attended by about 100 seismologists from more than 10 countries, was devoted mainly to the current state of theoretical and computational means of study of seismic wave propagation in complex structures. The special issue can be of interest for theoretical, global and explorational seismologists. The first part contains papers dealing with the study and the use of...

Differential equations - partial as well as ordinary - are one of the main tools for the modeling of real world application problems. Pursuing the ultimate aim of influencing these systems in a desired way, one is confronted with the task of optimizing discretized models. This volume contains selected papers presented at the International Work shop on "Fast Solution of Discretized Optimization Problems," which took place at the Weierstrass Institute for Applied Analysis and Stochastics in Berlin from May 08 until May 12, 2000. The conference was attended by 59 scientists from 10 countries....

Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ss, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the...

DNA fingerprinting had a well-defined birthday. In the March 7, 1985 issue of Nature, Alec Jeffreys and coworkers described the first develop- ment ofmu1tilocus probes capable of simultaneously revealing hypervari- ability at many loci in the human genome and called the procedure DNA fingerprinting. It was a royal birth in the best British tradition. In a few months the emerging technique had permitted the denouement of hith- erto insoluble immigration and paternity disputes and was already heralded as a major revolution in forensic sciences. In the next year (October, 1986) DNA...