MMPs are involved in numerous biological processes, fostering tissue degradation resulting in pathologies from osteoarthritis to tumor metastasis. This book focuses on the latest quantitative research into the endogenous inhibitors that disrupt MMP activity.

The Conference timetable had to be so arranged as to spread the main topics over several separate sessions. It was therefore decided to publish the material in these Proceedings under nine subject headings, irrespective of session. Within each chapter, which is preceded by a list of the sessions featuring the subject, all papers, invited and contributed, whether presented at the Conference or accepted for publication only, have been arranged in some lo- gical order. The reports of the four Panel Discussions were edited or summarized by the respective Moderator in consultation with Panel...

One of the most interesting aspects of thermogenesis research is that it quite naturally attracts workers from an extremely wide spectrum of interests, ranging from the mechanism of cellular respiratory control at the molecular level and neuro-hormonal control of energy dissipation both at the cellular level and that of the whole organisms to the mechanism of temperature control during the hibernating cycle and that of cold acclimatation. Thus, the Satellite Symposium on "The Effectors of Thermogenesis" brought together not only physiologists, but also biochemists, pharmacologists, zoologists...

This book brings together lmportant work on the structure and function of the dehydrogenases requiring nicotinamide coenzymes. The structure and function of lactate dehydrogen- ase, alcohol dehydrogenase, and glyceraldehyde 3-phosphate dehydrogenase are compared. These are the relatively simple oligomeric dehydrogenases for which very extensive structural and mechanistic information is available. Kinetic studies are dealt with in general terms, with selected examples. Genetic and structural relationships revealed by primary structure are discussed. General features of the specificity of...

In spite of all emphasis on objectivity, a scientific discipline needs for its development outstanding research workers with exceptional personal qualities. A scientist with these qualities is honoured here, on the occasion of his 70th birthday, by his pupils, friends and colleagues: Arthur Linder is respected as a researcher, advisor and teacher in the field of Applied Statistics. Professor Dr. Dr. h. c. A. Linder has demonstrated the utility of statistical methods in science and technology; these are recognised today as being essen- tial for an objective evaluation of data. His contacts...