Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled The Second Decade and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways mediated by these receptors warrant further research, even though in principle they appeared to represent the most immediate, seemingly simple signaling pathway from hormone (ligand)...
Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten y...
The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion and for the removal of potentially harmful, damaged, or misfolded proteins, and it controls protein activity by regulating protein-protein interactions and subcellullar localization. The ubiquitin system is thus involved in processes as diverse as cell cycle progression, signal tra- duction, gene transcription, and DNA repair. Not surprisingly, defects in the ubiquitin system have been linked with numerous diseases such as cancer, in?ammation,...
The ubiquitin system has two major functions in eukaryotic cells: it r- ulates protein degradation, which is essential for normal cellular fu- tion an...
Based on the international workshop GPCRs: From Deorphanisation to Lead StructureIdentification, held in Berlin in May 2006, the book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by leading experts in the field, discussing the most recent state of the art. They give insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. The book reflects the actual...
Based on the international workshop GPCRs: From Deorphanisation to Lead StructureIdentification, held in Berlin in May 2006, the...
Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21-23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of...
Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further ...
This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with ba...
Protein phosphorylation is an essential post-translational modification that modulates cell cell communication. Substrate phosphorylation by protein kinases controls intracellular signal transduction pathways that mediate cell proliferation, migration, differentiation, and metabolism. The importance of the protein kinase family is underscored by numerous disease states that arise due to dysregulation of kinase activity. Recent progress in understanding the molecular regulation of kinases has led to the development of new therapeutics based on the inhibition of kinase activity. Inhibitors...
Protein phosphorylation is an essential post-translational modification that modulates cell cell communication. Substrate phosphorylation by protei...
In 1920s, Otto Warburg described the phenomenon of aerobic glycolysis, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on...
In 1920s, Otto Warburg described the phenomenon of aerobic glycolysis, the ability of tumour cells to convert glucose to lactate in the presence of...
New developments in the field of high resolution imaging focus on functional parameters pertaining to disease-specific medical imaging. Such new diagnostic strategies are possible using scintigraphic techniques and, more recently, by MRI and US. In addition, new therapeutic concepts, including gene therapy, require specific tracers or contrast media for therapy monitoring, for example, enzyme activity and changes in receptor expression. For this purpose scientists conducting basic research, expecially molecular biologists, and clinicians must collaborate in order to exploit the available...
New developments in the field of high resolution imaging focus on functional parameters pertaining to disease-specific medical imaging. Such new diagn...
Investigations into the mechanisms of spennatogenesis, sperm matura tion and fertilization provide the basis of our understanding of male re productive physiology. Since in recent years molecular and cellular en docrinology has provided particularly important contributions to our knowledge, the European Workshops on Molecular and Celluar Endo crinology of the Testis, held regularly during even years since 1980, have become a prominent forum for researchers in the field to discuss recent findings and exchange new ideas. The most recent of these Testis Workshops, the 7th, was held on May 5 -...
Investigations into the mechanisms of spennatogenesis, sperm matura tion and fertilization provide the basis of our understanding of male re productiv...
In recent years the importance of adjuvants for optimising the activity of agrochemicals has become increasingly recognized. This book is aimed at accumulating the current knowledge of the interactions between adjuvants, agrochemicals and target organisms. It provides results, and ideas for future research and defines new methodological, biomechanistic and systematic approaches which can be implemented to streamline research and development of formulations and adjuvant/active ingredient combinations. The book contains micrographs of leaf surfaces and spray deposits, graphical and statistical...
In recent years the importance of adjuvants for optimising the activity of agrochemicals has become increasingly recognized. This book is aimed at acc...
