Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.
Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energeti...
This book is based on papers presented at a Symposium held in Seoul, Korea in 1992. The idea for the symposium developed naturally from work in which Professor Yung E Earm, at Seoul National University, had been involved both in my laboratory in Oxford and in his own laboratory in Seoul concerning the possible role of certain amino acids, like taurine that are strongly concentrated by the cells of the heart, and the relationship between such acids and membrane ionic currents. The first obvious question was whether it is possible to identify the transport mechanisms involved for taurine and...
This book is based on papers presented at a Symposium held in Seoul, Korea in 1992. The idea for the symposium developed naturally from work in which ...
Nature is totally amoral There are at least 3-4 million people in France alone who suffer from arterial hypertension, and whose cardiovascular system is submitted day and night to both a haemodynamic and hormonal stress. In all cases, the vasculature hypertrophies as does the myocardium. This growth process is obviously mainly detrimental at the outset since it lowers compliance of the arteries and makes them stiffer. In contrast, myocardial hypertrophy is initially beneficial since the growth process multiplies the number of contractile units and by so doing improves external work. In...
Nature is totally amoral There are at least 3-4 million people in France alone who suffer from arterial hypertension, and whose cardiovascular system...
Each year over 400,000 people have a new onset of heart failure in the United States, adding to a current patient population of over 4.8 million Americans. Basics of Heart Failure takes a problem-solving approach to examining heart failure and to providing the reader with an up-to-date account of our knowledge in this area. Chapters on the diagnosis and therapy of heart failure emphasize data from recent multicenter trials.
Each year over 400,000 people have a new onset of heart failure in the United States, adding to a current patient population of over 4.8 million Ameri...
After a certain age, one is elderly, aged, venerable, and patriarchal. Or just plain old. When I became old, I did not know it. I do know it now because of a syndrome of which I had previously been unaware. It is quite simple-when it hurts, it works; when it doesn't hurt, it doesn't work! Writing about the old is a preoccupation of the young, and that is as it should be because it is the young who must carry the burden of the old. I don't know the average age of the contributors to Franz Messerli's book, but I would guess it to be less than 50, which to me is positively pubescent! For many...
After a certain age, one is elderly, aged, venerable, and patriarchal. Or just plain old. When I became old, I did not know it. I do know it now becau...
Autopsy derives from the greek word autopsia, which means act of seeing with one's own eyes. It remains the most objective and accurate method to understand human. disease. Unfortunately, the volume of autopsies in teaching hospitals has decreased dramatically over the past years. The crucial factors that account for this are the recent progress and development of new technologies, especially in diagnostic imaging, immunology, cell biology and genetics. Additionally, the perpetual fear of legal liability by physicians accounts for its further decline. Consequently, physicians and medical...
Autopsy derives from the greek word autopsia, which means act of seeing with one's own eyes. It remains the most objective and accurate method to unde...
W. KUPPER Coronary artery vasoconstriction is not only the mechanism responsible for Prinzmetal's variant angina, but may also be involved in stable angina pectoris and myocardial infarction. However, the underlying patho-physiological mecha- nisms and the importance of coronary vasoconstriction in these syndromes is still largely unknown. Several hypotheses have been proposed. Sympathetic nervous activity plays a key role in the regulation of coronary blood flow, but mechanical or humoral constrictive factors may be active as well. a-adrenergic tone Adrenergic nerve fibers accompany coronary...
W. KUPPER Coronary artery vasoconstriction is not only the mechanism responsible for Prinzmetal's variant angina, but may also be involved in stable a...
In the thirty years since the advent of efTective pharmacologic treatment for hypertension, the world ofthe hypertensive has been transformed beyond recog nition. The first change involved only malignant hypertensives with enough residual renal parenchyma to survive. Such a hypertensive could trade inevitable renal failure - unless an intracerebral bleed occurred first - for a rigid regimen which prevented his blood pressure from destroying him but which was asso ciated with nearly intolerable side effects. Over the next 20 years, increasing numbers of patients with hypertension of decreasing...
In the thirty years since the advent of efTective pharmacologic treatment for hypertension, the world ofthe hypertensive has been transformed beyond r...
It is not often that one one writes the foreword for a book based on a conference which contributed so much to our knowledge in the field of hypertension. During my close association with the International Society of Hypertension from 1978-1982, numerous satellite symposia were held in connection with five interna tional meetings. The specific topics addressed in this volume, the quality of the contributions, and the superb expertise of the contributors make this monograph one of the most outstanding publications that the International Society of Hyper tension has sponsored. Satellite...
It is not often that one one writes the foreword for a book based on a conference which contributed so much to our knowledge in the field of hypertens...
