Radiochemical methodology constitutes the most important base for the successful functioning of a PET group in the routine production and development of radiopharmaceuticals. Of the several hundred products which have been labelled with positron emitters during the past two decades about 35 are presently considered to be of major interest. The time for a state-of-the-art review is right, since this field has advanced over the past fifteen years to reach a level where guidelines can now be suggested. Chapters of this book deal with each of the main methodological aspects of the chemistry...

Despite enormous efforts, over 100,000 papers and over $22 billion spent by the US taxpayer alone, the HIV-AIDS hypothesis has failed to produce any public health benefits, no vaccine, no effective drug, no prevention, no cure, not a single life saved. Is the science system to be blamed? Has science failed to reveal the truth about AIDS?
In AIDS: Virus or Drug Induced?, two dozen scientists, scholars and journalists have investigated the status quo of AIDS research. Most of them have questioned the HIV-AIDS hypothesis before, but have since been censored, and sociologically...

From guppies to Galapagos finches and from adaptive landscapes to haldanes, this compilation of contributed works provides reviews, perspectives, theoretical models, statistical developments, and empirical demonstrations exploring the tempo and mode of microevolution on contemporary to geological time scales. New developments, and reviews, of classic and novel empirical systems demonstrate the strength and diversity of evolutionary processes producing biodiversity within species. Perspectives and theoretical insights expand these empirical observations to explore patterns and mechanisms of...

Although interest in evolutionary novelties can be that these different mechanisms cooperate in the mak traced back to the time of Darwin, the appreciation ing of new genes. In the second phase of new gene evolution, conventional models of new gene evolution, and systematical experimental pursuit of the origin and evolution of new gene functions did not appear for example by gene duplication, held that the muta until the early years of last decade. Since the 1970s, tions fixed in the early stages of the new genes are Susumu Ohno, Walter Gilbert, and others from the assumed to be neutral or...

This book brings together most of the information available concerning two species that diverged 2-3 million years ago. The objective was to try to understand why two sibling species so similar in several characteristics can be so different in others. To this end, it was crucial to confront all data from their ecology and biogeography with their behavior and DNA polymorphism. Drosophila melanogaster and Drosophila simulans are among the two sibling species for which a large set of data is available. In this book, ecologists, physiologists, geneticists, behaviorists share their data on the two...

Frontiers in Magnetism of Reduced Dimension Systems presents a definitive statement of our current knowledge and the state of the art in a field that has yet to achieve maturity, even though there are a number of potential applications of thin magnetic films and multilayers, such as magnetic sensors, data storage/retrieval media, actuators, etc.
The book is organized into 13 chapters, each including a lecture and contributed papers on a similar subject. Five chapters deal with theoretical descriptions of electron transport phenomena, relaxation processes, nonlinear paramagnetic...

This volume derives from a series of lectures delivered as the general course' at the Hague Academy of International law in July 1989. Like those lectures, this volume does not pretend to provide a complete treatise covering all international law. Rather, it offers a particular perspective on the principal subjects of traditional international law, elaborates new developments, and dares reexamine assumptions and premises. The book is built on three themes. The first addresses law as politics, and international law as the law of a political system, now comprised of more than 180 separate,...

During the last 50 years, the perception oftransposable elements (TEs) has changed considerably from selfish DNA to sequences that may contribute significantly to genome function and evolution. The recent increased interest in TEs is based on the realization that they are a major genetic component (at least 10--20%) of all organisms and a major contributor to the mutation process. It is currently estimated that 70--80% of spontaneous mutations are the result of TE-mediated insertions, deletions, or chromosomal rearrangements. Thus, it seems at least plausible that TEs may playa significant...

Pathophysiology of Heart Failure brings together leading basic scientists and clinicians, presenting new approaches to this complex problem, involving cardiomyopathic processes and ischemia perfusion injury. The result is a synthesis of state-of-the-art information on molecular biology, cellular physiology and structure-function relationships in the cardiovascular system. The role which excess intracellular calcium plays in the genesis of cardiac dysfunction is described as a fundamental mechanism underlying heart failure; one which may lead to improved prevention and treatment....