Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice.

This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination,...

The field of neural transplantation is at a crucial stage, with important clinical trials on transplantation in patients with Parkinson's disease nearing completion and novel, alternative approaches to fetal transplantation being developed.

This timely book brings together leading neuroscientists, clinicians, and cell and developmental biologists to discuss the use of neural transplants in neurodegenerative disorders, such as Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis and spinal cord injury. There is also extensive coverage of the potential...

This book brings together scientists working at the interface between the cell cycle, cell growth and development in a variety of model systems and research paradigms. The focus is on understanding how such diverse developmental inputs can modulate cell cycle regulation and, reciprocally, how a common way of regulating cell cycle progression can participate in different developmental strategies.

This important book covers the structure and molecular biology of small round structured viruses (SSRVs) such as caliciviruses and astroviruses, and the basic pathology of infection. It provides readers with the knowledge needed to make progress in the prevention and treatment of these infections. Readers will also find an overview of gastroentitis vaccines, their structure and molecular biology, as well as the basic pathology of infection, epidemiology and surveillance.

• Provides an interdisciplinary approach, offering contributions from basic and clinical research
• Discusses...

This important and exciting work brings together a high-calibre group of experts to discuss the practical application of genomic information to the development of drugs. Recent technological advances have led to a rapid acceleration in our ability to gather genetic data. The complete genetic sequences are now known for several organisms and accelerated programmes are in place for sequencing many other genomes, including human. The speed with which complete sequencing can be accomplished will continue to increase as new technologies come online. In principle, the scope for developing new...

Antimony, arsenic, bismuth, germanium, lead, selenium, tellurium and tin just some of the elements which, in trace amounts, have biological, environmental and technological importance. Hydride Generation Atomic Absorption Spectrometry describes one of the most accurate analytical techniques for trace analysis of these elements, sensitive to picogram levels. Over the last decade, significant instrumental and methodological progress has led to HG-AAS being widely applied to an extensive range of sample types. In this first comprehensive monograph on HG-AAS, the authors treat both theoretical...

Non-living organic matter (NLOM) comprises the bulk of the organic carbon stored in the terrestrial biosphere and a major part of the organic carbon in the sea. Organic substances, which include litter, marine detritus, dissolved organic matter and soil organic matter, have diverse effects on the Earth's biogeochemical processes and serve as a major reservoir of biospheric carbon, which can be transformed to carbon dioxide, methane and other greenhouse gases.