The Monroes have gone on vacation, leaving Harold and Chester at Chateau Bow-Wow -- not exactly a four-star hotel. On the animals' very first night there, the silence is pierced by a peculiar wake-up call -- an unearthly howl that makes Chester observe that the place should be called Howliday Inn.

But the mysterious cries in the night (Chester is convinced there are werewolves afoot) are just the beginning of the frightening goings-on. Soon animals start disappearing, and there are whispers of murder. Is checkout...

Before it's too late, Harold the dog and Chester the cat must find out the truth about the newest pet in the Monroe household -- a suspicious-looking bunny with unusual habits...and fangs