Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In...

This book results from various lectures given in recent years. Early drafts were used for several single semester courses on singular perturbation meth- ods given at Rensselaer, and a more complete version was used for a one year course at the Technische Universitat Wien. Some portions have been used for short lecture series at Universidad Central de Venezuela, West Vir- ginia University, the University of Southern California, the University of California at Davis, East China Normal University, the University of Texas at Arlington, Universita di Padova, and the University of New Hampshire,...

This monograph is an outgrowth of the authors' recent research on the de velopment of algorithms for several low-level vision problems using artificial neural networks. Specific problems considered are static and motion stereo, computation of optical flow, and deblurring an image. From a mathematical point of view, these inverse problems are ill-posed according to Hadamard. Researchers in computer vision have taken the "regularization" approach to these problems, where one comes up with an appropriate energy or cost function and finds a minimum. Additional constraints such as smoothness,...

This book is written for ecologists and protozoologists. Ecologists who study environments and biotic communities in which protozoa are im ponant should find this book especially useful. During the last decade it has become clear that protozoa play important roles in natural eco systems, but few ecologists have a feeling for the functional properties and the diversity of these organisms. Protozoa pose or exemplify many general problems of population and community ecology, and of evo lutionary biology. In most respects the general ecological propenies of protozoa are not fundamentally...