Acute and chronic hepatitis and hepatitis-related diseases such as liver failure, liver cirrhosis and hepatocellular carcinoma are among the most important causes for disabilities and death. Hepatocellular injury is due to a variety of agents including viruses, toxins, radiation, injury and drugs but also bacteria, parasites and autoimmune reactions. This volume reviews today's knowledge about hepatitis with emphasis on comparative aspects between hepatitis in humans and animals, but also between different etiological agents. This particular viewpoint makes the book relevant for scientists...
Acute and chronic hepatitis and hepatitis-related diseases such as liver failure, liver cirrhosis and hepatocellular carcinoma are among the most impo...
The common cold is unlike any other human disease because of two f- tors: firstly, it is arguably the most common human disease and, secondly, it is one of the most complex diseases because of the number of viruses that cause the familiar syndrome of sneezing, sore throat, runny nose and nasal congestion. These two factors have made a 'cure' for the common cold one of the most difficult scientific and clinical endeavours (a topic often d- cussed in the popular media, where comparisons are made with the ease of putting a man on the moon). The present book brings together a wide range of...
The common cold is unlike any other human disease because of two f- tors: firstly, it is arguably the most common human disease and, secondly, it is o...
A quantum leap in technology has revolutionized the study of influenza and the engineering of new vaccine strains by reverse genetics. This volume provides a historical background and state-of-the-art information about the recent advances in the biology of influenza and the design of new influenza vaccines.
A quantum leap in technology has revolutionized the study of influenza and the engineering of new vaccine strains by reverse genetics. This volume pro...
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilitie...
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new...
Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilitie...
As individuals age, their ability to respond to and clear pathogens and to control unwanted immune reactions declines, leading to a greater incidence of certain infectious diseases, autoimmunity and general immune dysfunctions. Most remarkably, the efficacy of vaccines is frequently decreased in elderly persons. Therefore, age-associated dysfunctions of the humoral and cellular immune responses have a strong clinical impact. Improving our understanding of the aged immune system is crucial in developing effective prevention and treatment programs that will facilitate healthy aging and...
As individuals age, their ability to respond to and clear pathogens and to control unwanted immune reactions declines, leading to a greater inciden...
Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated "immune-privileged sites" by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against...
Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence o...
Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanisms are involved in these infections and an understanding of the pathogenesis is essential in understanding the diagnostic and clinical management aspects of the disease. Specialized investigations are often necessary for definitive diagnosis, although a presumptive diagnosis should often be suspected on the basis of the clinical features. Many of the chapters in this book are written by neurologists who are experts in basic science research of...
Viral infections of the nervous system are important because they are associated with high morbidity and mortality. A variety of pathogenetic mechanis...
This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. Last but not least, the role of AMP in HIV infection and the immunomodulatory properties of AMP highlight the diverse facets of AMP in host immunity.
This book focuses on the importance of human antimicrobial peptides (AMP) in keeping the host healthy and preventing infectious diseases. Last but not...
This book provides a useful text for research students and scientists on the latest knowledge about the immune system of fish, cutting edge technologies and the step required to develop, test and commercialise fish vaccines.
This book provides a useful text for research students and scientists on the latest knowledge about the immune system of fish, cutting edge technologi...
