From the Reviews of the Previous Volumes
"The authority, originality, and editing of the reviews are first class."
-NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
-JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin...

Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses.

• Covers viral assembly using heterologous expression systems and cell extracts
• Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA...

Protein Transcription is a key element of cellular and organ regulation. Proteins in Eukaryotic Transcription covers structure and function of all major elements associated with transcription.

• Mechanism of RNA polymerase I Transcription
• Structure and function of RNA Polymerase II
• Structure and function of the TFIID complex
• Functional properties of Chromatin Remodeling Enzymes
• Posttranslational modification

Cell Surface Receptors contains an extensive discussion of cell surface receptors in 11 chapters by experts in their field. As cell surface receptors are involved in almost every aspect of signaling throughout the body, the topic has been of high interest in the community in recent years.

Selected Contents:

• Structures of Axon Guidance Molecules and Their Neuronal Receptors
• Shared Cytokine Signaling Receptor
• NKG2D and Related Immunoreceptors
• Inonotropic Glutamat Receptor Recognition and Activation
• Chemotaxis Receptors and...

DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.

Selected Contents:

• Base Excision Repair
• Eukaryotic DNA Mismatch Repair
• Double Strand Break Repair
• Functions of DNA...

Fibrous Protein: Coiled-Coils, Collagen and Elastomers is the first of a three-part series on Fibrous Proteins. The books are based on a very successful workshop in Alpbach, Austria on the general topic of Fibrous Proteins that gave rise to the award winning issue of Journal of Structural Biology. Part II will contain an extensive discussion of Molecular Motors and Muscle, Part III on Amyloids, Prions and Beta Proteins.

Advances in Protein Chemistry is available online on ScienceDirect - full-text online of volumes 53 onwards.

• Reveals new structural and...

Volume 72, Peptide Solvation and H-bonds, addresses the role of peptide backbone solvation in the energetics of protein folding. Particular attention is focused on modeling and computation. This volume will be of particular interest to biophysicists and structural biologists.

• Challenges the longstanding and basic assumptions of structural biology
• Discusses how to solve the problem of protein structure prediction
• Addresses the quantitation of the energetics of folding

This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GƒNƒnƒnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho...

Amyloids, Prions and Beta Proteins is the last volume of the three-part thematic series on Fibrous Proteins in the Advances in Protein Chemistry serial. Fibrous proteins act as molecular scaffolds in cells providing the supporting structures of our skeletons, bones, tendons, cartilage, and skin. They define the mechanical properties of our internal hollow organs such as the intestines, heart, and blood vessels. This volume covers such topics as Beta-Structures in Fibrous Proteins; B-Silks: Enhancing and Controlling Aggregation; Beta-Rolls, Beta-Helices and Other Beta-Solenoid...