In the present volume and in the preceding one we have stretched our normal pattern of reviews by including articles of more major proportions than any we have published before. As a consequence each of these two vol- umes contains only three review articles. From the beginning of this series it has been our aim, as editors, to achieve variation in the scope, style, and length of individual articles sufficient to match the needs of the individual topic, rather than to restrain the authors within rigid limits. We feel that the two major articles of Vols. 5 and 6 are entirely justified and do...