Ontological Engineering refers to the set of activities that concern the ontology development process, the ontology life cycle, the methods and methodologies for building ontologies, and the tool suites and languages that support them. During the last decade, increasing attention has been focused on ontologies and Ontological Engineering. Ontologies are now widely used in Knowledge Engineering, Artificial Intelligence and Computer Science; in applications related to knowledge management, natural language processing, e-commerce, intelligent integration information, information retrieval,...

8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biologicalresearchhasshiftedfromgenomesequencestoproteinfunctionality. Withwhole-genomedraftsofmouseandhumaninhand, scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erenttissues, its3Dstructureandactivesites, itsfunctionalandstructural binding partners, and its subcellular location. Protein...

Probabilistic Modelling in Bioinformatics and Medical Informatics has been written for researchers and students in statistics, machine learning, and the biological sciences. The first part of this book provides a self-contained introduction to the methodology of Bayesian networks. The following parts demonstrate how these methods are applied in bioinformatics and medical informatics. All three fields - the methodology of probabilistic modeling, bioinformatics, and medical informatics - are evolving very quickly. The text should therefore be seen as an introduction, offering...

This book brings together high quality articles exploring the design, implementation, management, funding, promotion and evaluation of networked information systems that advocate sustainability and the protection of natural ecosystems. Case studies of deployed and planned information systems complement theoretical work on the methodological, technological and organizational foundations of environmental online communication.

Evolutionary Multiobjective Optimization is a rare collection of the latest state-of-the-art theoretical research, design challenges and applications in the field of multiobjective optimization paradigms using evolutionary algorithms. It includes two introductory chapters giving all the fundamental definitions, several complex test functions and a practical problem involving the multiobjective optimization of space structures under static and seismic loading conditions used to illustrate the various multiobjective optimization concepts.

Important features include:...

Enterprise Modelling (EM) methods are frequently used by entrepreneurs as an analysis tool for describing and redesigning their businesses. The resulting product, an enterprise model, is commonly used as a blueprint for reconstructing organizations and such effort is often a part of business process re-engineering and improvement initiatives.

Automating Business Modelling describes different techniques of providing automated support for enterprise modelling methods and introduces universally used approaches. A running example of a business modelling method is...

Multiobjective Evolutionary Algorithms and Applications provides comprehensive treatment on the design of multiobjective evolutionary algorithms and their applications in domains covering areas such as control and scheduling. Emphasizing both the theoretical developments and the practical implementation of multiobjective evolutionary algorithms, a profound mathematical knowledge is not required.

Written for a wide readership, engineers, researchers, senior undergraduates and graduate students interested in the field of evolutionary algorithms and multiobjective...

What we profoundly witness these days is a growing number of human-centric systems and a genuine interest in a comprehensive understanding of their underlying paradigms and the development of solid and efficient design practices. We are indeed in the midst of the next information revolution, which very likely brings us into a completely new world of ubiquitous and invisible computing, Ambient Intelligent (AMI), and wearable hardware. This requires a totally new way of thinking in which cognitive aspects of design, cognitive system engineering and distributed approach play a pivotal role. This...

Space support in databases poses new challenges in every part of a database management system & the capability of spatial support in the physical layer is considered very important. This has led to the design of spatial access methods to enable the effective & efficient management of spatial objects.

R-trees have a simplicity of structure & together with their resemblance to the B-tree, allow developers to incorporate them easily into existing database management systems for the support of spatial query processing.

This book provides an extensive survey of the R-tree...

The growth in the amount of data collected and generated has exploded in recent times with the widespread automation of various day-to-day activities, advances in high-level scienti?c and engineering research and the development of e?cient data collection tools. This has given rise to the need for automa- callyanalyzingthedatainordertoextractknowledgefromit, therebymaking the data potentially more useful. Knowledge discovery and data mining (KDD) is the process of identifying valid, novel, potentially useful and ultimately understandable patterns from massive data repositories. It is a...