1. Introduction of Druggable Lipid Signaling Pathway
Yasuyuki Kihara
2. Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development
William J. Valentine, Tomomi Hashidate-Yoshida, Shota Yamamoto, Hideo Shindou
3. Druggable Prostanoid Pathway
Liudmila L. Mazaleuskaya and Emanuela Ricciotti
4. Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress
Theresa Ramalho, Nayara Pereira, Stephanie L. Brandt, and Henrique Serezani
5. Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation
Cindy McReynolds, Christophe Morisseau, Karen Wagner, and Bruce Hammock
6. Druggable Sphingolipid Pathway
Victoria Blaho
7. Druggable Lysophospholipid Pathway
Keisuke Yanagida and William J. Valentine
8. Druggable targets in endocannabinoid signaling
Ann M. Gregus and Matthew W. Buczynski
9. Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections
Jacob A. McPhail and John E. Burke
10. Druggable Lipid GPCRs: Past, Present, and Prospects
Hirotaka Mizuno and Yasuyuki Kihara
Professor Kihara is a Research Assistant Professor at the Sanford Burnham Prebys Medical Discovery Institute in San Diego, California. His translational research is focused on G-protein coupled receptors and their role in disease.
This edited work presents a series of reviews focusing on Druggable Lipid Signaling Pathways. It enables researchers in both academic institutions and industry as well as physicians to understand historical aspects of lipid signaling and future directions of drug discovery targeting lipid signaling pathways. This book provides 9 pathways including acyltransferases, prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, phosphoinositides, and lipid GPCRs.
Readers will discover the importance of each lipid signaling pathway that contributes to broad range of diseases including neurological and neuropsychiatric diseases, pain, metabolic syndromes, cardiovascular diseases, cancer, dermatological diseases, fibrosis, inflammation, etc. Also, readers will recognize that many drugs targeting lipid signaling have been clinically used. Drugs currently under development are also discussed in each chapter, which includes some information about clinical trials and strategic drug designs.