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Tourette's syndrome (TS) is an inheritable, childhood-onset neuropsychiatric disorder characterized by the presence of motor and phonic tics. Despite decades of extensive studies, the exact disease etiology remains poorly understood. It is believed that susceptibility to TS is determined by the interactions of multiple genetic loci with unknown environmental factors. As a result, a great deal of research has been focused on identifying TS susceptibility genes. Thus far, at least 12 susceptibility loci have been suggested by genome-wide screenings, but none of them has been replicated probably...

Multirate Switched-Capacitor Circuits for 2-D Signal Processing introduces the concepts of analog multirate signal processing for the efficient implementation of two-dimensional (2-D) filtering in integrated circuit form, particularly from the viewpoints of silicon area and power dissipation. New 2-D switched-capacitor (SC) networks and design techniques are presented, both with finite impulse response (FIR) and infinite impulse response (IIR) with separable denominator polynomial, which offer simpler and more systematic synthesis procedures than currently available design techniques...