Diabetes Mellitus: Pathophysiology and Therapy: Bayer AG Centenary Symposium Edinburgh, U.K., May 25-28, 1988

ISBN-13: 9783540505068 / Angielski / Miękka / 1989 / 354 str.

Werner Creutzfeldt; Pierre J. Lefebvre

Opis

His scientific contributions are regarded as classics: the studies about the insulin effect on adipose tissue (together with George F. Cahill Jr. ), his work on the biosyn thesis and secretion of insulin (together with Lelio Orci and Claes W ollheim) and his studies on various spontaneous and induced diabetes syndromes in rodents (together with Bernard Jeanrenaud and Eleazar Shafrir). Albert Renold will be remembered for a long time by all who knew him for his achievements, for his kindness and his humanity. We dedicate the Proceedings of this symposium to his memory. Werner Creutzfeldt Pierre Lefebvre G6ttingen Liege History and Philosophy of Bayer Pharmaceutical Research W. -D. Busse Fachbereich Forschung Pharma, Bayer AG, D-5600 Wuppertal, FRG Research has a long tradition at Bayer. This year, 1988, marks 100 years of our pharmaceutical activities. In 1888 the first Bayer drug - phenacetin, an antipyreti- was synthesized, starting from a by-product of dye manufacture. This finding led to the establishment of a Pharmaceutical Department within Friedrich Bayer and Co. in Elberfeld, with all its associated facilities (Fig. 1). The beginning of the company itself, however, dates back to 1863. In that year, Friedrich Bayer started the produc tion of aniline dyestuffs in his private house in Barmen-Rittershausen. During the 125 years of the company's life and the 100 years of pharmaceuticals, many developments and products have been discovered by Bayer researchers and launched by Bayer."

Spis treści

Pathophysiology.- Etiology.- Epidemiology — Its Contribution to Understanding of the Etiology, Pathogenesis, and Prevention of Diabetes Mellitus.- Genetics of Diabetes Mellitus.- On the Pathogenesis of Insulin-Dependent Diabetes Mellitus — A Discussion of Three Recently Proposed Models.- Challenging Views on the Pathogenesis of Type I (Insulin-Dependent) Diabetes Mellitus.- Islet Amyloid and Type 2 Diabetes.- Physiology and Pathophysiology.- Insulin Receptor: Role of Receptor Tyrosine Kinase in Insulin Signalling and Action.- The Kinetics of Insulin, C-Peptide, and Proinsulin in Normal and Diabetic Man.- Cell Biology of Insulin Action on Glucose Transport and Its Perturbation in Diabetes Mellitus.- Mechanisms of Insulin Resistance in Obese and Type II Diabetic Subjects.- Abnormal Glucagon Secretion in Type 2 (Noninsulin-Dependent) Diabetes Mellitus: Causes and Consequences.- Animal Models.- Physiopathology and Possible Etiology of Hormonal Dysregulations and Insulin Resistance in Obese Rats: a Potential Model for Some Human Obesity.- Models for Studying Diabetic Complications.- Pharmacology.- Insulin Analogues — Potentials for Improving Diabetes Treatment.- Metabolic Inhibitors in the Treatment of Diabetes Mellitus.- Inhibitors Influencing Carbohydrate Absorption.- Therapy.- Comprehensive Approach to the Treatment of Diabetes Mellitus.- Why and How to Involve the Diabetic Patient in his Treatment.- Prevention of Late Complications.- Advanced Non-Enzymatic Tissue Glycosylation: Biochemical Basis of Late Diabetic Complications.- Is it Possible to Prevent Late Complications of Diabetes Mellitus?.- Recent Aspects of Insulin Therapy.- Long-Term Efficacy and Safety of Intensified Insulin Treatment Strategies.- Is Human Insulin Better than Animal Insulin in the Treatment of Insulin-Dependent Diabetes Mellitus?.- Specific Problems of Diabetes Mellitus in Youth.- Natural History of Diabetes Mellitus in Children.- Particular Aspects of the Management of Diabetes in Children.- The Pregnant Diabetic.- The State of the Art in Diabetic Pregnancy.- Relationship Between Maternal Glucose Levels and Congenital Malformations in the Infant of the Diabetic Mother.- Pancreas and Islet Transplantation.- State of the Art in Pancreas Transplantation.- What Future for Islet Transplantation in Man?.- Diet.- Aims of Diet in Diabetes Management.- Practicability of Diet in Diabetes Management.- New Aspects of Diabetes Treatment.- Induction of Partial Remission and Enhancement of Beta-Cell Function By Cyclosporin in Type I Diabetes.- Role of Abnormal Free Fatty Acid Metabolism in the Pathogenesis and Treatment of Noninsulin-Dependent Diabetes Mellitus.