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Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data...

AI in the 1980s and Beyond provides an inside report on current applications, trends, and future opportunities in one of the world's major centers of artificial intelligence research. The topics covered include a general perspective on AI, knowledge-based systems, expert systems tools and techniques, system building in medical diagnosis, AI and software engineering, intelligent natural language processing, automatic speech recognition, intelligent vision, seeing robots, robot programming, robot tactile sensing, and autonomous mobile robots. W. Eric L. Grimson and Ramesh S. Patil are both...