1. Introduction2. Ablation Techniques Overview3. Mathematics and Finite Element Method of Thermal Ablation Therapy4. Clinical Applications of Thermal Ablation5. Ablation Probes6. COMSOL Multiphysics Software for Ablation System Simulation7. Simulation-driven Modelling of Radiofrequency Ablation System8. Simulation-driven Modelling of Microwave Ablation System9. Image-Guided based Thermal Ablation Therapy10. Challenges and Future Research Directions