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*Groundbreaking - First book to explore data mining within a grid computing environment. *Applied -First book to investigate data mining and grid computing by examining the experiences and lesson learned from a major, real-world case study. *Accessible - Takes a conceptual, practical approach.

Complex systems modeling and simulation approaches are being adopted in a growing number of sectors, including finance, economics, biology, astronomy, and many more. Technologies ranging from distributed computing to specialized hardware are explored and developed to address the computational requirements arising in complex systems simulations.

The aim of this book is to present a representative overview of contemporary large-scale computing technologies in the context of complex systems simulations applications. The intention is to identify new research directions in this...

In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its ability to simultaneously measure the activity and interactions of thousands of genes, this modern technology promises unprecedented new insights into mechanisms of living systems. Currently, the primary applications of microarrays include gene discovery, disease diagnosis and prognosis, drug discovery (pharmacogenomics), and toxicological research (toxicogenomics). Typical scientific tasks addressed by microarray experiments include the...

As natural phenomena are being probed and mapped in ever-greater detail, scientists in genomics and proteomics are facing an exponentially growing vol ume of increasingly complex-structured data, information, and knowledge. Ex amples include data from microarray gene expression experiments, bead-based and microfluidic technologies, and advanced high-throughput mass spectrom etry. A fundamental challenge for life scientists is to explore, analyze, and interpret this information effectively and efficiently. To address this challenge, traditional statistical methods are being complemented by...

As natural phenomena are being probed and mapped in ever-greater detail, scientists in genomics and proteomics are facing an exponentially growing vol ume of increasingly complex-structured data, information, and knowledge. Ex amples include data from microarray gene expression experiments, bead-based and microfluidic technologies, and advanced high-throughput mass spectrom etry. A fundamental challenge for life scientists is to explore, analyze, and interpret this information effectively and efficiently. To address this challenge, traditional statistical methods are being complemented by...

This volume of the Springer Lecture Notes in Computer Science series contains the contributions presented at the International Symposium on Knowledge Exploration in Life Science Informatics (KELSI 2004) held in Milan, Italy, 25 26 November 2004. The two main objectives of the symposium were: To explore the symbiosis between information and knowledge technologies and v- ious life science disciplines, such as biochemistry, biology, neuroscience, medical research, social sciences, and so on. To investigate the synergy among different life science informatics areas, including cheminformatics,...

A Practical Approach to Microarray Data Analysis is for all life scientists, statisticians, computer experts, technology developers, managers, and other professionals tasked with developing, deploying, and using microarray technology including the necessary computational infrastructure and analytical tools. The book addresses the requirement of scientists and researchers to gain a basic understanding of microarray analysis methodologies and tools. It is intended for students, teachers, researchers, and research managers who want to understand the state of the art and of the presented...

In the past several years, DNA microarray technology has attracted tremendous interest in both the scientific community and in industry. With its ability to simultaneously measure the activity and interactions of thousands of genes, this modern technology promises unprecedented new insights into mechanisms of living systems. Currently, the primary applications of microarrays include gene discovery, disease diagnosis and prognosis, drug discovery (pharmacogenomics), and toxicological research (toxicogenomics). Typical scientific tasks addressed by microarray experiments include the...

The book constitutes the refereed proceedings of the International Workshop on Distributed, High-Performance and Grid Computing in Computational Biology, GCCB 2006, held in Eilat, Israel in January 2007 in conjunction with the 5th European Conference on Computational Biology, ECCB 2006. The 13 revised full papers presented were carefully reviewed and selected from many high quality submissions.

This book constitutes the refereed proceedings of the International Workshop on Knowledge Discovery in Life Science Literature, KDLL 2006, held in conjunction with the 10th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2006). The 12 revised full papers presented together with two invited talks were carefully reviewed and selected for inclusion in the book. The papers cover all topics of knowledge discovery in life science data.